Andrey Rublev, the eighth seed from Russia, stopped Britain's Jack Draper's run at Flushing Meadows.
Alexander Zverev of Germany battled past sixth seed Jannik Sinner in a five-set thriller to book a quarter-final meeting with Carlos Alcaraz.
Wimbledon champion Martketa Vodrousova will face Madison Keys in the women’s last eight, but last year’s runner-up Ons Jabeur bowed out 6-2 6-4 to China’s Qinwen Zheng, who will play new world number one Aryna Sabalenka.
Match of the day
Wimbledon champion Marketa Vondrousova moved a step closer to back-to-back grand slam titles by beating Peyton Stearns to the quarter-finals.
The 24-year-old Czech, seeded ninth here two months after becoming the first unseeded woman to win at SW19, fell a set behind to Stearns.
But the American youngster, whose powerful forehand accounted for Britain’s Katie Boulter in round three, won just five more games as Vondrousova triumphed 6-7 (3) 6-3 6-2.
Brit watch
Jack Draper’s breakthrough run came to an end in the fourth round after a four-set defeat by Russian Rublev.
The British number four, in the second week of a grand slam for the first time, fell 6-3 3-6 6-3 6-4
But Draper’s performances this week will hopefully point to an upward curve in such a promising career hindered by fitness issues.
Fallen seeds
Women: Jessica Pegula (3), Ons Jabeur (5), Daria Kasatkina (13).
Men: Jannik Sinner (6), Alex De Minaur (13).
Who’s up next?
The quarter-finals begin with Coco Gauff taking on Iga Swiatek’s conqueror Jelena Ostapenko.
Novak Djokovic follows against Taylor Fritz, while in the night session, there is an all-American showdown to savour between Frances Tiafoe and Ben Shelton.
