Erik ten Hag could have a selection headache ahead of the 2024/25 season after two more players came off early in a pre-season match.
Marcus Rashford and Antony were forced off in their 3-2 friendly win over Real Betis, although the full extent of their injuries have yet to be revealed.
Ten Hag had already lost £52million signing Leny Yoro and Rasmus Hojlund to fitness issues during the pre-season tour of the United States.
It was reported on Wednesday night that Yoro will miss three months with a foot injury, while Hojlund's hamstring strain will sideline him until September.
Rashford scored from the penalty spot in the victory over Betis, but walked off in discomfort before the hour mark after he took a whack to his right ankle.
Antony was one of eight players sent on at Snapdragon Stadium, but could not finish the match.
The Brazilian forward exited in the 86th minute and looked disconsolate as he headed straight down the tunnel.
It provided an unsatisfactory end to an otherwise productive evening as United continue preparations ahead of their Community Shield clash with rivals Manchester City on August 10.
