The NFL will return to London in October with Wembley and Tottenham Hotspur Stadium hosting the games.
Minnesota Vikings will face the New York Jets on October 6, before Chicago Bears tackle the Jacksonville Jaguars a week later – both at Tottenham's ground.
Wembley will then host Jaguars against the New England Patriots on October 20, the NFL announced.
"We have played games in London since 2007, and there has never been greater interest in the sport here," the NFL's UK and Ireland general manager Henry Hodgson said.
Jaguars owner Shahid Khan added: "We've worked hard over the past decade-plus to establish the Jacksonville Jaguars as the home team for NFL fans in London, the United Kingdom and now Ireland.
"Playing back-to-back games in London for the second consecutive year speaks to that commitment."
Bayern Munich's Allianz Arena, meanwhile, will host Carolina Panthers against the New York Giants on November 10.
