Olivier Peslier is to ride Telescope in the King George VI And Queen Elizabeth Stakes at Ascot on July 25.
The Sir Michael Stoute-trained five-year-old has been partnered by Ryan Moore on 12 of his 14 career starts but the former champion is on the sidelines after a stalls incident at Newmarket. His father, Gary Moore, said at the weekend he would be out for "more than a month".
Peslier will be hoping the silks of Telescope's owners Highclere Thoroughbred Racing again prove lucky in the race, as he sported the same colours in a brilliant victory aboard Harbinger in 2010.
Telescope was last seen finishing down the field in the Hardwicke Stakes at Royal Ascot won by stablemate Snow Sky.
A statement on the Highclere website read: "Sir Michael Stoute has confirmed that Telescope will have the King George VI And Queen Elizabeth Stakes as his next target.
"This year at Royal Ascot the ground was not in his favour and the pace set by the eventual winner Snow Sky was far too slow. Telescope is a very strong travelling horse and needs a proper Group One pace to be at his very best, so hopefully with the King George hotting up with entries such as Golden Horn, this year's contest will be a truly-run race.
"Golden Horn has shown himself to be head and shoulders above all his rivals so far this season, winning the Dante, Derby and Eclipse, but Telescope has been knocking on the door in Group One company for a while and heads to Ascot with as a good a chance as he had last year.
"Olivier Peslier, who won the King George on Harbinger five years ago, is booked to ride."
