Paddington will face five rivals as he bids to extend his winning sequence to seven.
Aidan O'Brien's ultra-progressive runner arrives seeking a fourth-straight Group 1-win following victories in the Irish 2,000 Guineas, the St James's Palace Stakes and the Coral-Eclipse.
The drop back to a mile will see him take on the John and Thady Gosden-trained filly Inspiral as she looks to bounce back from finishing second to Triple Time in the Queen Anne at Royal Ascot on her sole start this season.
The three-time Group 1 winning filly looks the obvious threat to Aidan O'Brien's short-priced favourite on Wednesday.
William Haggas' Aldaary, Richard Hannon's consistent Chindit and the Roger Varian-trained Charyn all feature in the field of six alongside French raider Facteur Cheval.
Paddington is a best-price 1/2 with Paddy Power to extend his winning run on the Sussex Downs this Wednesday, while Inspiral sits next in the market at 10/3.